Scientists reveal HIV cell mystery

Melbourne researchers

in reference to: Scientists reveal HIV cell mystery (view on Google Sidewiki)
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Protein that destroys HIV discovered

Treatments that would knock out HIV inhumans

in reference to:

"Protein that destroys HIV discovered"
- Protein that destroys HIV discovered | KurzweilAI (view on Google Sidewiki)
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3 Powerful Antibodies May Hold The Cure for HIV

Government scientists say the have discovered 3 powerful antibodies.

in reference to: The Black Urban Times: Black Man May Hold The Cure for HIV (view on Google Sidewiki)
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Possible HIV Cure or AIDS Cure?

Is Stem Cell Therapy a Cure for HIV and AIDS. The Simple answer is: "Yes, it is very Possible"

in reference to: Can Stem Cell Therapy Cure HIV and AIDS?: The Simple Answer is: "Yes, It is Very Possible" (view on Google Sidewiki)

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Potential of Stem Cells to Cure HIV

Source: www.timesofindia.com

Looked upon as a potential cure for HIV, the CCR5 gene and its deletion allele (CCR5-∆32) have been much studied since their discovered involvement in HIV infection. Approximately 5% to 14% of Europeans have the CCR5-∆32 allele, but it is absent in African, East Asian, and Native American populations. The mutation is thought to have arisen over 5000 years ago, casting aside theories that it was caused by positive selection during the bubonic plague (Sabeti et al., 2005). While heterozygous CCR5-∆32 individuals (having only one copy of CCR5-∆32) lessen HIV infection, individuals homozygous for CCR5-∆32 confer very high HIV resistance, though they make up approximately only 1% of the European population (Hütter et al., 2009; Liu et al., 1996; Lederman et al., 2006). Homozygous individuals have no apparent health problems. Based off of the known resistance the CCR5-∆32 mutation creates, anti-HIV drugs have been created that bind the CCR5 receptor, preventing HIV binding (Lederman et al., 2006).
A few weeks ago it was reported that a 40-year-old Caucasian patient with leukemia and HIV underwent hematopoietic stem cell transplants using peripheral blood from a donor homozygous for CCR5-∆32 and, over 20 months later, not only has the leukemia gone into complete remission, but the patient has no HIV detectable in his body either (Hütter et al., 2009). Before the transplant, the patient was on highly active antiretroviral therapy (HAART), the combined use of several antiretroviral drugs that has been found most effective in decreasing mortality rates caused by AIDS (Palella et al., 1998). The patient ceased taking HAART immediately prior to undergoing chemotherapy, due to the toxicity of the powerful drugs, but after the following stem cell transplant he has not since resumed the therapy and there have been no detectable signs of HIV in his system. The CCR5-∆32 homozygous hematopoietic stem cells appear to have replaced his irradiated immune system with CCR5-∆32 homozygous, HIV-resistant cells. Previously, hematopoietic stem cell transplants have been attempted to cure patients with both HIV and leukemia with some success (Sorà et al., 2001; Huzicka, 1997), but none used CCR5-∆32 homozygous donors.
References

Hütter, G., Nowak, D., Mossner, M., Ganepola, S., Müßig, A., Allers, K., Schneider, T., Hofmann, J., Kücherer, C., Blau, O., Blau, I. W., Hofmann, W. K., and Thiel, E. Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation. N. Engl. J. Med. 2009. 360:692-8.

To read case studies on a proven simple and natural HIV cure, which can be administered at home.

Natural HIV cure found?

Houston Lab disarms AIDS virus

Posted by XLPharmacy at Wellsphere discussion forum

There is real hope that what’s happening in a Houston lab might lead to a cure for HIV. HIV AIDS Research story and video

Houston researchers state that they have found an innovative way to kill the virus by finding this small region of HIV that is unchangeable.

Dr. Paul and Dr. Miguel Escobar aren’t talking about just suppressing HIV – they’re talking about destroying it permanently by arming the immune system with a new weapon lab tests have shown to be effective.

Dr. Paul thinks he’s cracked a code.

Dr. Paul believes that they have discovered the weak spot of HIV. Paul and his team have zeroed in on a section of a key protein in HIV’s structure that does not mutate.

In explanation it's like this: the virus needs at least one constant region, and by taking advantage of something called an abzyme. It’s naturally produced by people, like lupus patients. When they applied that abzyme to the HIV virus, it permanently disarmed it.

Dr. Paul states that what they already have in our hands are the abzymes that we could be infusing into the human subjects with HIV infection, essentially to move the virus...

Basically, their idea could be used to control the disease for people who already have it and prevent infection for those at risk.

The theory has held up in lab and animal testing. The next step is human trials.
If Dr. Pauls research is true than viral loads will fall to manageable levels, and that will preclude the need for these conventional drugs.

Still, even if everything goes well, it’s at least five years before the research could help people with HIV.

The doctors know there are millions of people waiting.

Why do you think that the Government isn't pumping huge funds into research that has promised so much. Why do we have to wait to know if this is something that will help our sons, daughters, fathers and mothers be cured of AIDS?
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